Omadacycline (PTK0796, BAY 73-6944, MK-2764) belongs to the aminomethylcyclines, a new subclass of the tetracyclines, and was designed to overcome resistance to that class (Honeyman et al. 2015). The chemical name for omadacycline is 7-dimethylamino, 9-(2,2-dimethyl-propyl)-aminomethylcycline. The empirical formula is C29H40N4O7 and the molecular weight is 556.7. The molecular structure of omadacycline is depicted in Figure 71.1. Its mechanism of action is similar to that of other tetracyclines, i.e., it binds to the bacterial ribosome, resulting in the inhibition of protein synthesis. There are intravenous as well as oral formulations.
|Organisation||Department of Medical Microbiology and Infectious Diseases|
Mouton, J.W. (Johan W.), & Nabuurs-Franssen, M.H. (Marrigje H.). (2017). Omadacycline. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 1267–1272). doi:10.1201/9781315152110