In the last years, the emerging threat of diabetes has called for resolution and intensified research efforts to analyse changing aspects of the epidemiology of traditional risk factors such as obesity and investigate the role of novel biomarkers in our ultimate aim to effectively prevent diabetes. The burgeoning interest in the field of epigenetics, an intersection between genetic determinism and environmental influences, has opened new opportunities to discover more about the molecular pathways involved in the regulation of diabetes risk factors from the etiological perspective, and possibly might give rise to new therapeutical strategies. Moreover, management and prevention of diabetes complications remain an exhaustive task not only for the diagnosed individual but also for the medical system. Patient-centered outcome measurements combined with efficient economical health systems, in what we now call value-based medicine, seem to be the new medical paradigm we are moving towards.

Additional Metadata
Keywords type 2 diabetes, obesity, epigenetics, fatty liver, dementia, value based medicine
Promotor O.H. Franco (Oscar) , M.A. Ikram (Arfan) , T. Muka (Taulant) , A. Dehghan (Abbas)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-182-4
Persistent URL
Note For copyright reasons there is a partial embargo for this dissertation
Nano, J. (2018, November 23). Epidemiology of Diabetes : Risk Factors and Adverse Outcomes. Erasmus University Rotterdam. Retrieved from