The following issues are discussed in the dissertation:
- The risk of venous thrombosis in antithrombin deficiency. The role of long-term anticoagulant therapy after a first VTE was investigated as well.
- The role of β-antithrombin and subtype of antithrombin deficiency in the risk of venous thrombosis.
- The way antithrombin deficiency influences the activity of heparins.
- The SerpinC1 gene mutations found in a Dutch cohort of families with antithrombin deficiency.
- Pregnancy, thrombophilia, and the risk of a first venous thrombosis.
- The association of antithrombin levels with the risk of first and recurrent arterial thromboembolism at a young age.
- The implications of the findings for current practice and future research.

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F.W.G. Leebeek (Frank) , K. Meijer (Karina)
Erasmus University Rotterdam
Department of Hematology

Croles, F. N. (2018, November 27). The role of antithrombin in venous and arterial thrombosis. Retrieved from