The following issues are discussed in the dissertation:
- The risk of venous thrombosis in antithrombin deficiency. The role of long-term anticoagulant therapy after a first VTE was investigated as well.
- The role of β-antithrombin and subtype of antithrombin deficiency in the risk of venous thrombosis.
- The way antithrombin deficiency influences the activity of heparins.
- The SerpinC1 gene mutations found in a Dutch cohort of families with antithrombin deficiency.
- Pregnancy, thrombophilia, and the risk of a first venous thrombosis.
- The association of antithrombin levels with the risk of first and recurrent arterial thromboembolism at a young age.
- The implications of the findings for current practice and future research.

Additional Metadata
Keywords Antithrombin, venous thrombosis, arterial thrombosis, pregnancy, SerpinC1, systematic review, Bayesian meta-analysis, heparin
Promotor F.W.G. Leebeek (Frank) , K. Meijer (Karina)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-190-9
Persistent URL hdl.handle.net/1765/112375
Note For copyright reasons there is a (partial) embargo for this dissertation
Citation
Croles, F.N. (2018, November 27). The role of antithrombin in venous and arterial thrombosis. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/112375