Dendritic cells (DCs) are critical for the activation of naïve CD4+ T cells and are considered professional antigen-presenting cells (APCs), as are macrophages and B cells. Recently, several innate type 2 immune cells, such as basophils, mast cells (MCs), eosinophils, and innate type 2 lymphocytes (ILC2), have also emerged as harboring APC behavior. Through surface expression or transfer of peptide-loaded MHCII, expression of costimulatory and co-inhibitory molecules, as well as the secretion of polarizing cytokines, these innate cells can extensively communicate with effector and regulatory CD4+ T cells. An exciting new concept is that the complementary tasks of these ‘amateur’ APCs contribute to shaping and regulating adaptive immunity to allergens and helminths, often in collaboration with professional APCs.

antigen presentation, antigen-presenting cells, basophils, innate lymphoid cells, mast cells, type-2 immunity,
Trends in Immunology
Department of Pulmonology

Schuijs, M.J, Hammad, H, & Lambrecht, B.N.M. (2018). Professional and ‘Amateur’ Antigen-Presenting Cells In Type 2 Immunity. Trends in Immunology. doi:10.1016/