The design of a microcomputer-controlled ventilator for automatic performance of lung function and circulatory tests has been described. It incorporates the characteristics of normal mechanical ventilation and also allows one to perform a multitude of test procedures for lung function and circulatory studies in paralyzed animals. The major components of the setup are a pump assembly with solenoid valves to direct gas flow, an electromechanical servo system, and a MS-DOS microcomputer system. The pump assembly has been constructed as a relatively simple device. Great versatility is created by the use of a microcomputer for the control of the ventilator. The software can be easily adapted to several other types of experimental studies. Besides the keyboard input the ventilator can be controlled by a remote computer system. This allows one to run an experimental protocol automatically and to use it in closed-loop servo ventilation. The flexibility in the choice of the respiratory parameters makes the ventilator suitable for lung function and circulatory studies during artificial ventilation. The ventilator has been successfully used in different animal studies during the last 6 yr.

artificial ventilation, assisted ventilation, breathing mechanics, circulation, computer analysis, controlled study, lung fuction, methodology
Journal of Applied Physiology
Erasmus MC: University Medical Center Rotterdam

Jansen, J.R.C, Hoorn, E, van Goudoever, J, & Versprille, A. (1989). A computerized respiratory system including test functions of lung and circulation. Journal of Applied Physiology, 67(4), 1687–1691. Retrieved from