2019-01-08
HIV Treatment Strategies – The role of integrase strand transfer inhibitors
Publication
Publication
HIV behandelstrategieën – de rol van integraseremmers
The studies that will be described in Chapter 2 to 8, and which resulted in this thesis, aim to evaluate the effectiveness and safety of new HIV treatment strategies with INSTIs, especially DTG, in HIV-1 infected individuals. Furthermore, several aspects of cART-toxicity with dual NRTI backbones in combination with an INSTI, PI, or NNRTI are evaluated. The ultimate goal is a more individualized and patient-centered therapy by balancing virological and immunological efficacy with reduction of the risk of adverse events.
This thesis focuses on three issues.
Part 1 focuses on the effects of a switch from triple cART to DTG as maintenance monotherapy.
In part 2 the safety of initiating INSTI-containing cART in HIV late presenters with compromised immunity on the risk of IRIS is discussed.
Part 3 concentrates on aspects regarding safety of the NRTI backbone in INSTI, PI, or NNRTI containing cART and possibilities to further individualize HIV treatment.
| Additional Metadata | |
|---|---|
| , , | |
| A. Verbon (Annelies) , B.J.A. Rijnders (Bart) , C. Rokx (Casper) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/112830 | |
| Organisation | Department of Internal Medicine |
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Wijting, I. (2019, January 8). HIV Treatment Strategies – The role of integrase strand transfer inhibitors. Retrieved from http://hdl.handle.net/1765/112830 |
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| Additional Files | |
|---|---|
| Stellingen-Ingeborg-Wijting.pdf , 154kb | |
| 112830_Chapter_1-General_introduction_and_outline_of_the.pdf Final Version , 1mb | |
| 112830_Chapter_2-Dolutegravir_as_maintenance_monotherapy.pdf Final Version , 566kb | |
| 112830_Chapter_3-HIV-1_resistance_dynamics_in_patients_wi.pdf Final Version , 1mb | |
| 112830_Chapter_4-Predictors_of_virological_failure_in_HIV.pdf Final Version , 416kb | |
| 112830_Chapter_5-Changes_in_renal-_bone-_lipid-_and_infla.pdf Final Version , 547kb | |
| 112830_Chapter_6-Immune_reconstitution_inflammatory_syndr.pdf Final Version , 1mb | |
| 112830_Chapter_7-Inosine_5_-triphosphatase_activity_is_as.pdf Final Version , 408kb | |
| 112830_Chapter_8-Switching_to_tenofovir_alafenamide_fumar.pdf Final Version , 459kb | |
| 112830_Chapter_9-Summarizing_discussion.pdf Final Version , 406kb | |
| 112830_Chapter_10-Nederlandse_samenvatting.pdf Final Version , 279kb | |
| 112830_Chapter_11-Publications_PhD_portfolio_Curriculum_V.pdf Final Version , 373kb | |