Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing salmonella enterica serovar typhimurium isolated from a case of fatal burn wound infection
Salmonella species are frequently associated with gastrointestinal infections such as diarrhea. However, extraintestinal Salmonella infections, including burn infections, have been described. Here, we report the first case of a carbapenem-resistant and metallo-β-lactamase (New Delhi metallo-β-lactamase), extended-spectrum β-lactamase (SHV-12), and AmpC β-lactamase (CMY-4) coproducing Salmonella Typhimurium isolated from a fatal case of burn wound infection. The publication highlights the necessity for the rational use of antibiotics (particularly the rational use of last-resort antibiotics such as carbapenems) in hospitals and burn units, as well as the need for systematic screening of Salmonella spp. (including Salmonella enterica serovar Typhimurium) for resistance to carbapenem antibiotics.
|Keywords||Coproduction, Extended-spectrum and AmpC β-lactamase, Fatal burn wound, Metallo-β-lactamase, Salmonella, Whole genome sequencing|
|Persistent URL||dx.doi.org/10.2147/IDR.S167027, hdl.handle.net/1765/112863|
|Journal||Infection and Drug Resistance|
Banerjee, K. (Kokila), Sekar, P. (Priyadharshini), Krishnan, P. (Padma), Wattam, A.R. (Alice Rebecca), Roy, S. (Subhendu), Hays, J.P, & Menezes, G.A. (2018). Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing salmonella enterica serovar typhimurium isolated from a case of fatal burn wound infection. Infection and Drug Resistance, 11, 2491–2495. doi:10.2147/IDR.S167027