Hypereosinophilia encompasses a broad differential diagnosis of atopy/allergic reactions, drug reactions, parasitic infections and paraneoplastic syndromes. Although mostly of limited clinical significance, hypereosinophilia can also be related to hematological malignancies. One has to be aware of the potential for secondary organ damage for example, in the case of hypereosinophilic syndrome. We present three cases with different underlying mechanisms of hypereosinophilia with a brief overview of causes, diagnostic work-up and treatment options.

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Keywords Allergy, Chronic eosinophilic leukemia, Corticosteroids, Hematological malignancy, Hypereosinophilia, Hypereosinophilia of unknown significance, Hypereosinophilic syndrome, Imatinib, Ivermectin, Mepolizumab, Parasitic infections, Strongyloïdiasis
Persistent URL hdl.handle.net/1765/113506
Journal The Netherlands Journal of Medicine
van Balkum, M. (M.), Kluin-Nelemans, H. (H.), van Hellemond, J.J, van Genderen, P.J.J, & Wismans, P.J. (2018). Hypereosinophilia: A diagnostic challenge. The Netherlands Journal of Medicine (Vol. 76, pp. 431–436). Retrieved from http://hdl.handle.net/1765/113506