Background: There is growing interest in linking vitamin D deficiency with autism spectrum disorders (ASDs). The association between vitamin D deficiency during gestation, a critical period in neurodevelopment, and ASD is not well understood. Aims: To determine the association between gestational vitamin D status and ASD. Method: Based on a birth cohort (n=4334), we examined the association between 25-hydroxyvitamin D (25OHD), assessed from both maternal mid-gestation sera and neonatal sera, and ASD (defined by clinical records; n=68 cases). Results: Individuals in the 25OHD-deficient group at mid-gestation had more than twofold increased risk of ASD (odds ratio (OR)=2.42, 95% confidence interval (CI) 1.09 to 5.07, P=0.03) compared with the sufficient group. The findings persisted in analyses including children of European ethnicity only. Conclusions: Mid-gestational vitamin D deficiency was associated with an increased risk of ASD. Because gestational vitamin D deficiency is readily preventable with safe, inexpensive and readily available supplementation, this risk factor warrants closer scrutiny.

Additional Metadata
Persistent URL dx.doi.org/10.1192/bjpo.bp.116.004077, hdl.handle.net/1765/113558
Journal British Journal of Psychiatry
Citation
Vinkhuyzen, A.A.E, Eyles, D.W, Burne, T.H, Blanken, L.M.E, Kruithof, C.J, Verhulst, F.C, … Mcgrath, J.J. (2017). Gestational vitamin D deficiency and autism spectrum disorder. British Journal of Psychiatry, 3, 85–90. doi:10.1192/bjpo.bp.116.004077