The aim of this thesis was to investigate the underlying mechanism associated with the alteration of renal microvascular oxygenation under different pathophysiological conditions, such as hemodilution, sepsis, I/R and hemorrhage, in conjunction with acute kidney injury.
Additionally, the influences of certain microcirculatory pathways that are manipulated by the administration of fluids, blood transfusion, ROS scavenging, detoxification and immune suppression on acute kidney injury were evaluated.

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D.A.M.P.J. Gommers (Diederik) , C. Ince (Can) , C.J. Zuurbier (Coert J.)
Erasmus University Rotterdam
Department of Intensive Care