The aim of this thesis was to investigate the underlying mechanism associated with the alteration of renal microvascular oxygenation under different pathophysiological conditions, such as hemodilution, sepsis, I/R and hemorrhage, in conjunction with acute kidney injury.
Additionally, the influences of certain microcirculatory pathways that are manipulated by the administration of fluids, blood transfusion, ROS scavenging, detoxification and immune suppression on acute kidney injury were evaluated.

Additional Metadata
Keywords Acute kidney injury, microcirculation, oxygenation, hemodynamic, critical illness
Promotor D.A.M.P.J. Gommers (Diederik) , C. Ince (Can) , C.J. Zuurbier (Coert J.)
Publisher Erasmus University Rotterdam
ISBN 978-94-6380-051-8
Persistent URL
Ergin, B. (2018, December 20). The renal microcirculation as a target for the treatment of acute kidney injury in models of critical illness. Erasmus University Rotterdam. Retrieved from