The renal microcirculation as a target for the treatment of acute kidney injury in models of critical illness
De renale microcirculatie als doelwit voor de behandeling van acute nierschade bij modellen van kritische ziekten
The aim of this thesis was to investigate the underlying mechanism associated with the alteration of renal microvascular oxygenation under different pathophysiological conditions, such as hemodilution, sepsis, I/R and hemorrhage, in conjunction with acute kidney injury.
Additionally, the influences of certain microcirculatory pathways that are manipulated by the administration of fluids, blood transfusion, ROS scavenging, detoxification and immune suppression on acute kidney injury were evaluated.
|Keywords||Acute kidney injury, microcirculation, oxygenation, hemodynamic, critical illness|
|Promotor||D.A.M.P.J. Gommers (Diederik) , C. Ince (Can) , C.J. Zuurbier (Coert J.)|
|Publisher||Erasmus University Rotterdam|
|Note||For copyright reasons there is a (partial) embargo for this dissertation|
Ergin, B. (2018, December 20). The renal microcirculation as a target for the treatment of acute kidney injury in models of critical illness. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/113908