We present a unique case of a patient with anti–dipeptidyl peptidase-like protein 6 (DPPX) encephalitis in which severe pruritus was the cardinal symptom. Anti-DPPX encephalitis is caused by cell surface autoantigens to DPPX, a subunit of the Kv4.2 potassium channel.1 Most patients had a combination of limbic encephalitis, brainstem dysfunction, diarrhea, and weight loss.1–3 We describe a patient with severe pruritus and provide long-term follow-up, offering recommendations for treatment

doi.org/10.1212/nxi.0000000000000455, hdl.handle.net/1765/114184
Neurology: Neuroimmunology and Neuroinflammation
Department of Neurology

Wijntjes, J., Bechakra, A.M., Schreurs, M., Jongen, J., Koppenaal, A., & Titulaer, M.J. (2018). Pruritus in anti-DPPX encephalitis. Neurology: Neuroimmunology and Neuroinflammation, 5(3). doi:10.1212/nxi.0000000000000455