Background: The GAS study is an international RCT to evaluate neurodevelopmental outcome comparing general plus regional anesthesia versus regional anesthesia alone in 722 neonates and infants who had inguinal hernia repair up to 60 weeks of postmenstrual age. This paper comprises a secondary descriptive analysis of hernias, aspects of surgery and outcomes. Methods: The incidence of unilateral and bilateral hernias, side preponderance, predictive factors for bilateral hernias and surgical approaches were collated. Follow-up outcome data were examined at 2 years. Results: Of 711 eligible patients, there were 679 with hernia data showing that 321 hernias were right-sided, 190 left and 168 bilateral. Male to female ratio was 5:1. Of those with unilateral hernias, 25.8% underwent contralateral exploration and in these cases a patent processus vaginalis was found in 68.9%. Bilateral hernias were more common in younger and female patients. At 2 years there was a recurrence rate of 0.99% and in 2.7% of patients a hernia was evident on the contralateral side (metachrony), and this was unrelated to the anesthesia technique. Conclusions: Bilateral hernias are associated with lower gestational age at birth and female gender. There was a low incidence of complications and the anesthesia technique did not affect surgical outcome. Level of evidence: Level 1 evidence from prospective treatment study.

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Keywords Anesthesia, Infant, Inguinal hernia repair, Neonate, Outcome
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Journal Journal of Pediatric Surgery
Disma, N. (Nicola), Withington, D. (Davinia), McCann, M.E. (Mary Ellen), Hunt, R.W. (Rodney Wayne), Arnup, S.J. (Sarah Jane), Izzo, F. (Francesca), … Pini Prato, A. (Alessio). (2018). Surgical practice and outcome in 711 neonates and infants undergoing hernia repair in a large multicenter RCT: Secondary results from the GAS Study. Journal of Pediatric Surgery, 53(9), 1643–1650. doi:10.1016/j.jpedsurg.2018.01.003