We studied 2240 indeterminate solid nodules (volume 50-500mm 3) to determine the correlation of diameter and semi-automated volume measurements for pulmonary nodule size estimation. Intra-nodular diameter variation, defined as maximum minus minimum diameter through the nodule's center, varied by 2.8 mm (median, IQR:2.2-3.7 mm), so above the 1.5 mm cutoff for nodule growth used in Lung CT Screening Reporting and Data System (Lung-RADS). Using mean or maximum axial diameter to assess nodule volume led to a substantial mean overestimation of nodule volume of 47.2% and 85.1%, respectively, compared to semi-automated volume. Thus, size of indeterminate nodules is poorly represented by diameter. Trial registration number Pre-results, ISRCTN63545820.

Additional Metadata
Keywords imaging/CT MRI etc, lung cancer
Persistent URL dx.doi.org/10.1136/thoraxjnl-2017-210770, hdl.handle.net/1765/114248
Journal Thorax: an international journal of respiratory medicine
Citation
Heuvelmans, M.A, Walter, J.E. (Joan E), Vliegenthart, R, van Ooijen, P.M.A, de Bock, G.H, De Koning, H.J. (Harry J.), & Oudkerk, M. (2018). Disagreement of diameter and volume measurements for pulmonary nodule size estimation in CT lung cancer screening. Thorax: an international journal of respiratory medicine, 73(8). doi:10.1136/thoraxjnl-2017-210770