Understanding the mechanisms of action of Mesenchymal Stem Cell (MSC) immunomotherapy contributes to generating more effective and safer therapy and can help to better treat patients with different immunological diseases. This thesis shows that upon the most common way of infusion, MSC function mainly as catalysts inducing immunosuppression through the host’s own immune cells. Monocytic cells seem to play an important role in the first step of inducing immunosuppression by altering their phenotype upon phagocytosis of MSC. Long term immunosuppressive effects seen in patients treated with MSC suggests that MSC primed innate immune cells induce a long term immune response by interaction with adaptive immune cells. Better understanding of this process to induce long term immunosuppression helps to provide novel and cell-free therapeutics to treat immunological disorders.

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Keywords Mesenchymal stem cells, mesenchymal stromal cells, immunotherapy, transplantation
Promotor C.C. Baan (Carla) , M.J. Hoogduijn (Martin)
Publisher Erasmus University Rotterdam
ISBN 978-94-6375-214-5
Persistent URL hdl.handle.net/1765/114250
Luk, F. (2019, January 15). Elucidation of the Mechanisms of Action of Mesenchymal Stem Cell Immunotherapy. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/114250