Channelopathies are disorders caused by abnormal ion channel function in differentiated excitable tissues. We discovered a unique neurodevelopmental channelopathy resulting from pathogenic variants in SCN3A, a gene encoding the voltage-gated sodium channel NaV1.3. Pathogenic NaV1.3 channels showed altered biophysical properties including increased persistent current. Remarkably, affected individuals showed disrupted folding (polymicrogyria) of the perisylvian cortex of the brain but did not typically exhibit epilepsy; they presented with prominent speech and oral motor dysfunction, implicating SCN3A in prenatal development of human cortical language areas. The development of this disorder parallels SCN3A expression, which we observed to be highest early in fetal cortical development in progenitor cells of the outer subventricular zone and cortical plate neurons and decreased postnatally, when SCN1A (NaV1.1) expression increased. Disrupted cerebral cortical folding and neuronal migration were recapitulated in ferrets expressing the mutant channel, underscoring the unexpected role of SCN3A in progenitor cells and migrating neurons. Smith et al. define a role for sodium channel SCN3A (NaV1.3) in the developing human cerebral cortex, as well as a cortical malformation that can result from NaV1.3 dysfunction.

Additional Metadata
Keywords Cortical Development, NaV1.1, NaV1.3, Oromotor, Outer Radial Glia, Polymicrogyria, SCN1A, SCN3A, Speech, Voltage-Gated Sodium Channel (VGSC)
Persistent URL dx.doi.org/10.1016/j.neuron.2018.07.052, hdl.handle.net/1765/114430
Journal Neuron
Citation
Smith, R.S. (Richard S.), Kenny, C.J. (Connor J.), Ganesh, V. (Vijay), Jang, A. (Ahram), Borges-Monroy, R. (Rebeca), Partlow, J.N. (Jennifer N.), … Lehtinen, M.K. (Maria K.). (2018). Sodium Channel SCN3A (NaV1.3) Regulation of Human Cerebral Cortical Folding and Oral Motor Development. Neuron, 99(5), 905–913.e7. doi:10.1016/j.neuron.2018.07.052