Treatment of malignant pleural mesothelioma (MPM) represents a highly unmet medical need. Here, we discuss the results and therapeutic potential of first- and second-generation immunomodulatory antibodies targeting distinct immune checkpoints for the treatment of MPM, as well as their prospective therapeutic role in combination strategies. We also discuss the role of appropriate radiological criteria of response for MPM and the potential need of ad hoc criteria of disease evaluation in MPM patients undergoing treatment with immunotherapeutic agents.

Additional Metadata
Keywords Immune checkpoint, Immunotherapy, Mesothelioma, NIBIT-2016
Persistent URL dx.doi.org/10.1007/s00262-018-2191-3, hdl.handle.net/1765/114695
Journal Cancer Immunology, Immunotherapy: other biological response modifications
Citation
Calabrò, L. (Luana), Morra, A. (Aldo), Cornelissen, R, Aerts, J.G.J.V, & di Maio, R. (2018). Immune checkpoint blockade therapy of mesothelioma: a clinical and radiological challenge. Cancer Immunology, Immunotherapy: other biological response modifications (Vol. 67, pp. 1317–1324). doi:10.1007/s00262-018-2191-3