This thesis sought to explore contemporary applications of invasive coronary angiography in the era of advanced percutaneous coronary intervention. Firstly, it describes the development and validation of dedicated bifurcation quantitative coronary angiography algorithms, in order to facilitate their analysis in a harmonized, reliable and reproducible manner. Then it presents the use of bifurcation quantitative coronary angiography algorithms in clinical studies, in the context of large registries and randomized trials, and discusses the clinical relevance of angiographic measures. Finally, it explores the prognostic value of angiographic scoring systems such as the SYNTAX score, and derivative scores such as the Clinical SYNTAX score and the coronary artery bypass graft (CABG) SYNTAX score.