To the Editor:
Pain treatment in patients with bone-metastasized advanced prostate cancer is often challenging. A range of treatment modalities are available to control prostate cancerespecific pain, such as androgen deprivation therapies, taxane-based chemotherapy, radionuclide therapy with radium-223, or palliative radiotherapy. In addition, analgesics are commonly used for direct symptom management.

We describe three cases which show difficulties of pain management in enzalutamide-treated patients with metastatic bone disease due to castrationresistant prostate cancer (CRPC). The potential illustrations of drug-drug interactions noted in these cases are of important clinical relevance. [...],
Journal of Pain and Symptom Management
Radboud University Nijmegen Medical Centre

Westdorp, H, Kuip, E.J.M, van Oort, I.M, Kramers, C, Gerritsen, W.R, & Vissers, K.C.P. (2018). Difficulties in Pain Management Using Oxycodone and Fentanyl in Enzalutamide-Treated Patients With Advanced Prostate Cancer. Journal of Pain and Symptom Management, 55(4), e6–e8. doi:10.1016/j.jpainsymman.2017.11.016