Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.

Additional Metadata
Keywords Dementia, epidemiology, glomerular filtration rate, kidney function, stroke
Persistent URL dx.doi.org/10.3233/jad-181086, hdl.handle.net/1765/115245
Journal Journal of Alzheimer's Disease
Koop-Nieuwelink, C, Sedaghat, S, Mutlu, U, Licher, S, Franco, O.H, Ikram, M.A, … Bos, D. (2019). Kidney Function and the Risk of Stroke and Dementia. Journal of Alzheimer's Disease, 67(3), 821–826. doi:10.3233/jad-181086