To determine whether classes of diabetes medications are associated with cognitive health and dementia risk, above and beyond their glycemic control properties.
Research design and methods
Findings were pooled from 5 population-based cohorts: the Framingham Heart Study, the Rotterdam Study, the Atherosclerosis Risk in Communities (ARIC) Study, the Aging GeneEnvironment Susceptibility-Reykjavik Study (AGES) and the Sacramento Area Latino Study on Aging (SALSA). Differences between users and non-users of insulin, metformin and sulfonylurea were assessed in each cohort for cognitive and brain MRI measures using linear regression models, and cognitive decline and dementia/AD risk using mixed effect models and Cox regression analyses, respectively. Findings were then pooled using meta-analytic techniques, including 3,590 individuals with diabetes for the prospective analysis.
After adjusting for potential confounders including indices of glycemic control, insulin use was associated with increased risk of new-onset dementia (pooled HR (95% CI) = 1.58

Additional Metadata
Persistent URL dx.doi.org/10.1002/uog.20201, hdl.handle.net/1765/115350
Journal Ultrasound in Obstetrics and Gynecology
Russo, F.M., Hooper, S., Tibboel, D, DeKoninck, P, Benachi, A, Treluyer, J.M., … Deprest, J. (2019). Antenatal therapy with sildenafil: don't throw the baby out with the bathwater. Ultrasound in Obstetrics and Gynecology, 53(2), 274–27+. doi:10.1002/uog.20201