We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thicknessand fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negativelycorrelated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α,Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and withlower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brainstructural and functional integrity in bipolar depression.

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Keywords Depression, Cytokines, Emotional processing
Persistent URL dx.doi.org/10.1016/j.pscychresns.2019.01.009, hdl.handle.net/1765/115552
Journal Psychiatry Research - Neuroimaging
Poletti, S, Leone, G., Hoogenboezem, T.A, Ghiglino, D., Vai, B, de Wit, H.J, … Benedetti, F. (2019). Markers of neuroinflammation influence measures of cortical thickness in bipolar depression. Psychiatry Research - Neuroimaging, 285, 64–66. doi:10.1016/j.pscychresns.2019.01.009