2019-04-01
Risk of bleeding in hospitalized patients on anticoagulant therapy
Publication
Publication
Prevalence and potential risk factors
European Journal of Internal Medicine , Volume 62 p. 17- 23
Introduction: Bleeding is the most important complication of treatment with anticoagulant therapy. Although
several studies have identified risk factors of bleeding in outpatients, no studies have been performed that
evaluated prevalence and potential risk factors of bleeding in hospitalized patients treated with anticoagulant
therapy.
Methods: The primary objective of this study was to determine the prevalence of bleeding in anticoagulant users
during hospitalization. The secondary objective was to identify potential risk factors of bleeding in hospitalized
patients on anticoagulant therapy.
A prospective, observational cohort study was conducted in two Dutch hospitals. Adult patients hospitalized
between October 2015 and October 2016 treated with anticoagulant therapy were included. Bleeding was defined as a composite endpoint of major bleeding and non-major bleeding according to the International Society
on Thrombosis and Heamostasis (ISTH) criteria. Data analysis was performed by multivariate logistic regression.
Results: The prevalence of in-hospital bleeding in patients using anticoagulant therapy was 7.2%; 95% confidence interval [95% CI] 5.5–9.1 (65 out of 906 patients). Multivariate logistic regression analysis indicated that
female gender (adjusted odds ratio [ORadj] 2.1; 95% CI 1.2–3.7), high-bleeding-risk surgical procedure (ORadj
5.3; 95% CI 2.7–10.2), low-bleeding-risk surgical procedure (ORadj 4.9; 95% CI 1.9–12.6), and non-surgical
interventions (ORadj 6.2; 95% CI 3.0–12.6) were associated with bleeding events in hospitalized patients treated
with anticoagulants.
Conclusions: The prevalence of bleeding in anticoagulant users during hospitalization was 7.2%. This study
detected potential risk factors that can help to identify patients on anticoagulants who have an increased risk of
bleeding during hospitalization.
Additional Metadata | |
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doi.org/10.1016/j.ejim.2019.01.008, hdl.handle.net/1765/116078 | |
European Journal of Internal Medicine | |
Organisation | Department of Clinical Chemistry |
Dreijer, A., Diepstraten, J., Brouwer, R., Croles, F. N., E. Kragten (Esther), Leebeek, F., … van den Bemt, P. (2019). Risk of bleeding in hospitalized patients on anticoagulant therapy. European Journal of Internal Medicine, 62, 17–23. doi:10.1016/j.ejim.2019.01.008 |