2019-04-01
Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies
Publication
Publication
Pediatrics (English Edition) , Volume 143 - Issue 4
ABO blood group incompatibility between mother and fetus can lead to hemolytic disease of the fetus and newborn (HDFN). We present the first case of severe O/A HDFN associated with extremely high-titer (1:32 000) immunoglobulin G anti-A antibodies in a Cameroon mother. Cord blood analysis revealed severe fetal hemolytic anemia and conjugated hyperbilirubinemia. After exclusion of an underlying disease and other risk factors, cholestasis resolved after treatment with ursodeoxycholic acid, a red blood cell transfusion, and intravenous immunoglobulins. This case is presented to create awareness for a more severe course of ABO HDFN in nonwhite and non-European mother-child pairs.
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| doi.org/10.1542/peds.2018-2859, hdl.handle.net/1765/116109 | |
| Pediatrics (English Edition) | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Zonneveld, R., van der Meer-Kapelle, L., Sylva, M., Brand, A., Zijlstra, M., & Schonewille, H. (2019). Severe Fetal Hemolysis and Cholestasis Due to High-Titer Maternal IgG Anti-A Antibodies. Pediatrics (English Edition), 143(4). doi:10.1542/peds.2018-2859 |
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