2019-03-18
ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer
Publication
Publication
Cancer Cell , Volume 35 - Issue 3 p. 401- +
Androgen deprivation therapy for prostate cancer (PCa) benefits patients with early disease, but becomes ineffective as PCa progresses to a castration-resistant state (CRPC). Initially CRPC remains dependent on androgen receptor (AR) signaling, often through increased expression of full-length AR (ARfl) or expression of dominantly active splice variants such as ARv7. We show in ARv7-dependent CRPC models that ARv7 binds together with ARfl to repress transcription of a set of growth-suppressive genes. Expression of the ARv7-repressed targets and ARv7 protein expression are negatively correlated and predicts for outcome in PCa patients. Our results provide insights into the role of ARv7 in CRPC and define a set of potential biomarkers for tumors dependent on ARv7.
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| doi.org/10.1016/j.ccell.2019.01.008, hdl.handle.net/1765/116113 | |
| Cancer Cell | |
| Organisation | Department of Pathology |
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Cato, L., de Tribolet-Hardy, J., van der Lee, I., Rottenberg, J.T., Coleman, I., Melchers, D., … Brown, M. (2019). ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cancer Cell, 35(3), 401–+. doi:10.1016/j.ccell.2019.01.008 |
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