Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.

Additional Metadata
Keywords First trimester, preeclampsia, external validation, prognostic model
Persistent URL dx.doi.org/10.1080/10641955.2019.1584210, hdl.handle.net/1765/116213
Journal Hypertension in Pregnancy
de Ruiter, M., Kwee, A, Naaktgeboren, CA, Louhanepessy, R.D., de Groot, I.B, Evers, IM, … Koster, M.P.H. (2019). External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort. Hypertension in Pregnancy, 38(2), 78–88. doi:10.1080/10641955.2019.1584210