External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort
Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results: 3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.
|Keywords||First trimester, preeclampsia, external validation, prognostic model|
|Persistent URL||dx.doi.org/10.1080/10641955.2019.1584210, hdl.handle.net/1765/116213|
|Journal||Hypertension in Pregnancy|
de Ruiter, M., Kwee, A, Naaktgeboren, CA, Louhanepessy, R.D., de Groot, I.B, Evers, IM, … Koster, M.P.H. (2019). External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort. Hypertension in Pregnancy, 38(2), 78–88. doi:10.1080/10641955.2019.1584210