development of hepatocellular carcinoma (HCC) worldwide. Determining the optimal approach for management of the viral infection and the HCC depends on the virus and the stage of the cancer. In patients with HCV-associated HCC, there are multiple reasons to frst treat the HCC. Firstly, in case of a curable HCC, the urgency for HCC treatment is important to avoid progression during HCV treatment. Secondly, the presence of HCC itself appears to reduce the rates of sustained virological response (SVR) achieved with direct-acting antivirals (DAAs). And fnally, the evidence does not support the concept of an increase in HCC recurrence due to DAAs, so a patient can safely be treated after HCC cure. For patients with very advanced HCC, the benefts of HCV therapy are questionable. In contrast, those who develop HCC in the setting of chronic HBV infection, treatment with nucleoside analogues (NAs) is recommended prior to treating HCC, to prevent further liver injury and reduce the risk for HCC recurrence. Ultimately, earlier diagnosis and treatment of HBV and HCV will hopefully reduce the incidence of HCC worldwide.

Additional Metadata
Keywords Hepatitis C virus (HCV) · Sustained virological response (SVR) · Hepatocellular carcinoma (HCC) · Directacting antivirals (DAAs) · Hepatitis B virus (HBV)
Persistent URL,
Journal Digestive Diseases and Sciences
Feld, J.J, & Krassenburg, L.A.P. (2019). What Comes First: Treatment of Viral Hepatitis or Liver Cancer?. Digestive Diseases and Sciences, 64(4), 1041–1049. doi:10.1007/s10620-019-05518-5