Absorb Bioresorbable Vascular Scaffold (BVS) for the treatment of coronary artery disease in clinical practice

Drug-eluting stents (DES) are widely used as first choice devices in percutaneous coronary interventions (PCI). However, certain concerns are associated with the use of DES, i.e. neo-atherosclerosis, late stent thrombosis and hypersensitivity reactions to the DES polymer. Bioresorbable scaffolds (BRS) such as the Absorb Bioresorbable Vascular Scaffold (BVS) are the next development within the field of PCI, introducing the concept of supporting the natural healing process following initial intervention without leaving any foreign body materials resulting in late adverse events. The first-generation devices have shown encouraging results in multiple studies of selected patients with non-complex lesions up to the point of full bioresorption. It supported the introduction in regular patient care. During its introduction in daily clinical practice outside the previous selected patient groups, a careful approach should be followed in which outcome is continuously monitored. The aim of this thesis was to investigate the safety and efficacy of the Absorb BVS in more complex lesions and higher-risk patients, when treated in a diverse clinical practice.

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