Clinical implications of DNA methylation for kidney transplantation
Klinische implicaties van DNA methylatie voor niertransplantatie
The main objective of this thesis is to explore the role of DNA methylation changes in complications after kidney transplantation. To answer this two complementary approaches
• First, we aim to unravel if environmental conditions relevant in transplantation affect DNA methylation; by investigating the stability of DNA methylation in experimental, in vitro systems in the presence of immunosuppressive drugs and cytokines.
• Second, we explore whether DNA methylation profiles can identify kidney transplant recipients who are at increased risk for rejection or skin cancer after kidney transplantation.
|Keywords||Epigenetics, T cell, Renal Transplantation, Rejection, Skin Malignancy|
|Promotor||C.C. Baan (Carla) , K. Boer (Karin) , M.G.H. Betjes (Michiel)|
|Publisher||Erasmus University Rotterdam|
Peters, F.S. (2019, May 15). Clinical implications of DNA methylation for kidney transplantation. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/116464