This thesis explores the utilization of HTA in the field of injury, mental healthcare and prevention with the aim of investigating the cost-effectiveness of interventions and improving the methodology of HRQOL measurement in injury patients. Different scientific approaches have been used, including systematic literature review, health-economic modeling, value of information analysis, and methodological research related to HRQOL measurement.

The aims of this thesis are threefold and will be addressed in separate parts of the thesis:
1. To review the cost-effectiveness of preventive interventions in the field of mental healthcare and injury and to assess the methodological quality of the studies (Part I: Evidence synthesis)
2. To assess the cost-effectiveness of preventive interventions for panic disorder and subfertility and to identify the main drivers of cost-effectiveness and uncertainty using health-economic modeling techniques (Part II: Cost-effectiveness modeling)
3. To investigate the value of alternative approaches for measuring HRQOL in injury patients by means of the EQ-5D-3L (Part III: Health-related quality of life)

Additional Metadata
Keywords Cost-effectiveness, Health Technology Assessment, Health economics, Injury, Mental health, Prevention, Quality of life
Promotor A. Burdorf (Alex) , S. Polinder (Suzanne) , J.A. Haagsma (Juanita)
Publisher Erasmus University Rotterdam
ISBN 978-94-028-1415-6
Persistent URL
Ophuis, R.H. (2019, May 29). Quantifying Efficiency in the Field of Injury, Mental Healthcare and Prevention. Erasmus University Rotterdam. Retrieved from