Quantifying Efficiency in the Field of Injury, Mental Healthcare and Prevention

This thesis explores the utilization of HTA in the field of injury, mental healthcare and prevention with the aim of investigating the cost-effectiveness of interventions and improving the methodology of HRQOL measurement in injury patients. Different scientific approaches have been used, including systematic literature review, health-economic modeling, value of information analysis, and methodological research related to HRQOL measurement.

The aims of this thesis are threefold and will be addressed in separate parts of the thesis:
1. To review the cost-effectiveness of preventive interventions in the field of mental healthcare and injury and to assess the methodological quality of the studies (Part I: Evidence synthesis)
2. To assess the cost-effectiveness of preventive interventions for panic disorder and subfertility and to identify the main drivers of cost-effectiveness and uncertainty using health-economic modeling techniques (Part II: Cost-effectiveness modeling)
3. To investigate the value of alternative approaches for measuring HRQOL in injury patients by means of the EQ-5D-3L (Part III: Health-related quality of life)