This thesis aims to improve risk stratification of patients with coronary artery disease. Parts 1 and 2, respectively known as “Vulnerable Blood” and “Vulnerable Period” aimed at elucidating the role of various serum biomarkers, and repeated measurements thereof, in order to identify patients at increased risk of myocardial infarction, and more specifically to identify the specific timeframe of that increased risk.

Part 3, “Vulnerable Plaque” is focused on invasive coronary imaging (coronary angiography, intravascular ultrasound and near-infrared spectroscopy) and the detection of prognostic plaque characteristics, as well as the relation between plaque components and serum biomarkers.
Part 4 “Intervention Studies” describes the search for those patient subsets to derive most benefit from current (pharmacologic) interventions in coronary artery disease.

Additional Metadata
Keywords Coronary artery disease, Myocardial infarction, Risk stratification, Biomarkers, Troponin, Intravascular ultrasound, Near-infrared spectroscopy
Promotor H. Boersma (Eric) , K.M. Akkerhuis (Martijn)
Publisher Erasmus University Rotterdam
Sponsor The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2007B012)
ISBN 978-94-6361-279-1
Persistent URL hdl.handle.net/1765/116703
Note For copyright reasons there is a partial embargo for this dissertation
Citation
Oemrawsingh, R.M. (2019, June 27). Coronary Vulnerability. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/116703


Additional Files
Cover-Coronary-Vulnerability.PNG Cover Image , 23kb
Stellingen-Rohit-Oemrawsingh-1-.pdf , 90kb
116703_Chapter_1-Prologue.pdf Final Version , 196kb
116703_Chapter_2-Multimarker_risk_model_containing_tropon.pdf Final Version , 381kb
116703_Chapter_3-Lipoprotein.pdf Final Version , 410kb
116703_Chapter_4-High-sensitivity_C-reactive_protein_pred.pdf Final Version , 363kb
116703_Chapter_5-Cohort_profile_of_BIOMArCS.pdf Final Version , 624kb
116703_Chapter_7-High-frequency_biomarker_measurements_of.pdf Final Version , 536kb
116703_Chapter_8-Rationale_and_design_of_the_ATHEROREMO-I.pdf Final Version , 435kb
116703_Chapter_9-Near-infrared_spectroscopy_predicts_card.pdf Final Version , 1mb
116703_Chapter_10-Near-infrared_spectroscopy-derived_lipi.pdf Final Version , 512kb
116703_Chapter_11-In_vivo_detection_of_high-risk_coronary.pdf Final Version , 910kb
116703_Chapter_12-Prognostic_value_of_intravascular_ultra.pdf Final Version , 1mb
116703_Chapter_13-SYNTAX_score_II_predicts_long-term_mort.pdf Final Version , 434kb
116703_Chapter_14-Relation_of_C-reactive_protein_to_coron.pdf Final Version , 2mb
116703_Chapter_15-High-Sensitivity_Troponin_T_in_Relation.pdf Final Version , 1mb
116703_Chapter_16-PCSK9_in_relation_to_coronary_plaque_in.pdf Final Version , 2mb
116703_Chapter_17-Circulating_chemokines_in_relation_to_c.pdf Final Version , 2mb
116703_Chapter_18-Circulating_cytokines_in_relation_to_th.pdf Final Version , 699kb
116703_Chapter_19-Von_Willebrand_Factor_in_relation_to_co.pdf Final Version , 2mb
116703_Chapter_20-Haptoglobin_polymorphism_in_relation_to.pdf Final Version , 688kb
116703_Chapter_21-Darapladib_effect_on_circulating_high_s.pdf Final Version , 442kb
116703_Chapter_22-Integrated_Biomarker_and_Imaging_Study.pdf Final Version , 621kb
116703_Chapter_23-Prediction_of_absolute_risk_reduction_o.pdf Final Version , 1mb
116703_Chapter_24-Individualized_ACE-inhibitor_Therapy_in.pdf Final Version , 1mb
116703_Chapter_25-Primary_PCI_during_off-hours_is_not_rel.pdf Final Version , 630kb
116703_Chapter_26-Summary_and_conclusions.pdf Final Version , 197kb
116703_Chapter_27-Dutch_Summary_Nederlandse_samenvatting.pdf Final Version , 187kb
116703_Chapter_28-List_of_publications.pdf Final Version , 213kb
116703_Chapter_29-PhD_Portfolio.pdf Final Version , 178kb
116703_Chapter_30-Acknowledgements_Dankwoord.pdf Final Version , 186kb
116703_Chapter_31-About_the_author_Curriculum_Vitae.pdf Final Version , 178kb