Introduction: Polyneuropathy with immunoglobulin M monoclonal gammopathy (IgM-PNP) is associated with the presence of IgM antibodies against nerve constituents such as myelin associated glycoprotein (MAG) and gangliosides. Methods: To test whether B-cell-stimulating cytokines are increased in IgM-PNP, we measured serum concentrations of 11 cytokines in 81 patients with IgM-PNP and 113 controls. Results: Median interleukin (IL)-6 concentrations were higher in patients with IgM-PNP, and median IL-10 concentrations were higher in the subgroup with anti-MAG IgM antibodies. These serum concentrations were not increased in 110 patients with multifocal motor neuropathy. Discussion: Median IL-6 and IL-10 serum concentrations differ between patients with anti-MAG neuropathy and other patients with IgM-PNP compared with healthy and neuropathy controls. These differences may indicate differences in immune-mediated disease mechanisms.

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Journal Muscle & Nerve
Stork, A.C.J, Rijkers, G.T, Vlam, L., Cats, E.A, de Jong, B.A.W., Fritsch-Stork, R. D. E., … van der Pol, W.-L. (2019). Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy. Muscle & Nerve, 59(6), 694–698. doi:10.1002/mus.26462