Background The impact of Aspergillus on lung disease in young children with cystic fibrosis is uncertain. Aims To determine if positive respiratory cultures of Aspergillus species are associated with: (1) increased structural lung injury at age 5 years; (2) accelerated lung function decline between ages 5 years and 14 years and (3) to identify explanatory variables. Methods A cross-sectional analysis of association between Aspergillus positive bronchoalveolar lavage (BAL) cultures and chest high-resolution CT (HRCT) scan findings at age 5 years in subjects from the Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) study was performed. A non-linear mixed-effects disease progression model was developed using FEV1 % predicted measurements at age 5 years from the AC FBAL study and at ages 6–14 years for these subjects from the Australian Cystic Fibrosis Data Registry. Results Positive Aspergillus BAL cultures at age 5 years were significantly associated with increased HRCT scores for air trapping (OR 5.53, 95% CI 2.35 to 10.82). However, positive Aspergillus cultures were not associated with either FEV1 % predicted at age 5 years or FEV1 % predicted by age following adjustment for body mass index z-score and hospitalisation secondary to pulmonary exacerbations. Lung function demonstrated a non-linear decline in this population. Conclusion In children with cystic fibrosis, positive Aspergillus BAL cultures at age 5 years were associated contemporaneously with air trapping but not bronchiectasis. However, no association was observed between positive Aspergillus BAL cultures on FEV1 % predicted at age 5 years or with lung function decline between ages 5 years and 14 years.

Additional Metadata
Persistent URL dx.doi.org/10.1136/thoraxjnl-2018-211550, hdl.handle.net/1765/116921
Journal Thorax: an international journal of respiratory medicine
Citation
Harun, S.N., Wainwright, C.E, Grimwood, K, Hennig, S., Cheney, J, George, N., … van der Wiel, E. (2018). Aspergillus and progression of lung disease in children with cystic fibrosis. Thorax: an international journal of respiratory medicine, 74(2), 125–131. doi:10.1136/thoraxjnl-2018-211550