Although chronic airflow limitation (CAL) is an important long-term consequence of tuberculosis (TB), little is known about the disease process. We present what we believe to be the first case of histologically confirmed residual TB-associated obstructive pulmonary disease (TOPD) in a 23-year-old non-smoking man who developed severe CAL after one episode of TB, with no other plausible risk factors. Lung biopsies identified residual post-TB pathology affecting the small airways and vessels throughout his lung; this has not been reported previously. These findings strengthen the argument that TOPD may be a phenotype of CAL distinct from both smoking-related chronic obstructive pulmonary disease and bronchiectasis.

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Keywords TB, chronic airflow obstruction, histology, lung function, post-TB
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Journal International Journal of Tuberculosis and Lung Disease
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Allwood, B.W., Rigby, J., Griffith-Richards, S., Kanarek, D., du Preez, L., Mathot, B., … Irusen, E. (2019). Histologically confirmed tuberculosis-associated obstructive pulmonary disease. International Journal of Tuberculosis and Lung Disease, 23(5), 552–554. doi:10.5588/ijtld.18.0722