2019-05-21
Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation
Publication
Publication
Nature Communications , Volume 10
Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2Bdependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation.
| Additional Metadata | |
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| doi.org/10.1038/s41467-019-09958-5, hdl.handle.net/1765/117127 | |
| Nature Communications | |
| Organisation | Department of Neuroscience |
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Lefort, J.M., Vincent, J, Tallot, L., Jarlier, F., de Zeeuw, C., Rondi-Reig, L., & Rochefort, C. (2019). Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation. Nature Communications, 10. doi:10.1038/s41467-019-09958-5 |
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