Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation
Cerebellar activity supported by PKC-dependent long-term depression in Purkinje cells (PCs) is involved in the stabilization of self-motion based hippocampal representation, but the existence of cerebellar processes underlying integration of allocentric cues remains unclear. Using mutant-mice lacking PP2B in PCs (L7-PP2B mice) we here assess the role of PP2Bdependent PC potentiation in hippocampal representation and spatial navigation. L7-PP2B mice display higher susceptibility to spatial map instability relative to the allocentric cue and impaired allocentric as well as self-motion goal-directed navigation. These results indicate that PP2B-dependent potentiation in PCs contributes to maintain a stable hippocampal representation of a familiar environment in an allocentric reference frame as well as to support optimal trajectory toward a goal during navigation.
|Persistent URL||dx.doi.org/10.1038/s41467-019-09958-5, hdl.handle.net/1765/117127|
Lefort, J.M., Vincent, J, Tallot, L., Jarlier, F, de Zeeuw, C.I, Rondi-Reig, L, & Rochefort, C. (2019). Impaired cerebellar Purkinje cell potentiation generates unstable spatial map orientation and inaccurate navigation. Nature Communications, 10. doi:10.1038/s41467-019-09958-5