Progress toward determining the true worth of ongoing practices or value of recent innovations can be glacially slow when we insist on following the conventional stepwise scientific pathway. Moreover, a widely accepted but flawed conceptual paradigm often proves difficult to challenge, modify or reject. Yet, most experienced clinicians, educators and clinical scientists privately entertain untested ideas about how care could or should be improved, even if the supporting evidence base is currently thin or non-existent. This symposium encouraged experts to share such intriguing but unproven concepts, each based upon what the speaker considered a logical but unproven rationale. Such free interchange invited dialog that pointed toward new or neglected lines of research needed to improve care of the critically ill. In this summary of those presentations, a brief background outlines the rationale for each novel and deliberately provocative unconfirmed idea endorsed by the presenter.

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Keywords Antibiotic overuse, Ascorbic acid, Innovation, Lactate, Lithium, Nanotechnology, Nutritional support, Paradigm, Post-intensive care syndrome, Subcellular microscopy
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Journal Critical Care
Marini, J.J. (John J.), Debacker, D. (Daniel), Gattinoni, L, Ince, C, Martin-Loeches, I, Singer, P, … Vincent, J.-L. (2019). Thinking forward: Promising but unproven ideas for future intensive care. In Critical Care (Vol. 23). doi:10.1186/s13054-019-2462-1