The clinical goals for the care of each patient with complex coronary artery disease are to ensure that the most appropriate treatment is selected, and the best available evidence is used to guide procedural techniques and modify risk factors that could impact life expectancy and health-related quality of life. In this thesis, efficient surgical techniques, post-procedural therapies, and the most critical determinants for clinical decision-making between surgical and catheter-based myocardial revascularization are explored, thereby helping patients and treating physicians to choose the most appropriate revascularization strategy and secondary prevention therapy based on an individualized risk-benefit ratio. With the increasing number of high-quality clinical studies and rigorously developed clinical practice guidelines, a future-directed intention needs to be the implementation of quality-improvement programs across clinical microsystems to increase the use of evidence­based practice in hospitals and outpatient settings to enhance the efficacy and safety of patient care.

Additional Metadata
Keywords Coronary artery disease, coronary artery bypass surgery, percutaneous coronary intervention, decision making, surgical techniques, optimal medical therapy
Promotor A.P. Kappetein (Arie Pieter) , S.J. Head (Stuart)
Publisher Erasmus University Rotterdam
Sponsor Nederlandse Hartstichting (Netherlands Heart Foundation)
ISBN 978-94-6380-382-3
Persistent URL
Milojevic, M. (2019, June 28). Decision Making in Patients Undergoing Coronary Artery Revascularization : A New Era in Clinical Trial Design and Evidence-Based Practice. Erasmus University Rotterdam. Retrieved from