We investigated whether there are similar serum alterations in schizophrenia and major depressive disorder (MDD). We investigated serum analytes in two epidemiological studies on schizophrenia (N = 121) and MDD (N = 1172) versus controls. Serum analytes (N = 109) were measured with a multi-analyte profiling platform and analysed using linear regression models, adjusted for site, age, gender, ethnicity, anti-inflammatory agents, smoking, cardiovascular disease and diabetes, and adjusted for multiple comparisons. An increase in leptin and insulin levels was observed for both schizophrenia patients (Cohen's d (d): 0.26 and 0.65, respectively) and MDD patients (d: 0.29 and 0.12, respectively) compared to their respective controls. Lower angiopoietin-2 levels were seen in both schizophrenia (d: -0.22) and MDD (d: -0.13). Four analytes differed in only schizophrenia patients (increased levels of C-peptide and prolactin, and decreased levels of CD5 antigen-like and sex hormone binding globulin) and one analyte differed in only MDD patients (increased angiotensinogen levels) compared to their respective controls. Restricting analyses to patients with a current episode of disease showed even more marked elevations of insulin and leptin. Our results suggest the presence of insulin and leptin resistance as cross-disorder mechanisms that could contribute to the higher somatic comorbidity and decreased life-span seen in both disorders.

Additional Metadata
Keywords Cross-disorder, Depressive disorder, Insulin resistance, Leptin, Proteomics, Schizophrenia
Persistent URL dx.doi.org/10.1016/j.euroneuro.2019.05.010, hdl.handle.net/1765/117440
Journal European Neuropsychopharmacology
Grant This work was funded by the European Commission 7th Framework Programme; grant id h2020/754740 - Immune Signatures for Therapy Stratification in Major Mood Disorders (MOODSTRATIFICATION)
Çakici, N. (Nuray), Essink-Bot, M.L.E, Lamers, F, Janssen, T. (Thomas), van der Spek, P.J, de Haan, L, … van Beveren, N.J.M. (2019). Increased serum levels of leptin and insulin in both schizophrenia and major depressive disorder: A cross-disorder proteomics analysis. European Neuropsychopharmacology. doi:10.1016/j.euroneuro.2019.05.010