Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

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Journal Cell Metabolism
Grant This work was funded by the European Commission 7th Framework Programme; grant id erc/310372 - The interaction landscape between microbial colonization and functional genome of the host: a systems biology approach in fungal infections (SYSBIOFUN)
Bekkering, S. (Siroon), Stiekema, L.C.A. (Lotte C.A.), Bernelot Moens, S. (Sophie), Verweij, S.L. (Simone L.), Novakovic, B. (Boris), Prange, K. (Koen), … Riksen, N.P. (Niels P.). (2019). Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia. Cell Metabolism, 30(1), 1–2. doi:10.1016/j.cmet.2019.05.014