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Bekkering, S. (Siroon), Stiekema, L.C.A. (Lotte C.A.), Bernelot Moens, S. (Sophie), Verweij, S.L. (Simone L.), Novakovic, B. (Boris), Prange, K. (Koen), Versloot, M. (Miranda), J.E. Roeters van Lennep (Jeanine), H. Stunnenberg (Henk), M.P.J. de Winther (Menno P.), et al. E.S.G. Stroes (Erik), L.A.B. Joosten (Leo), M.G. Netea (Mihai) and Riksen, N.P. (Niels P.)

2019-07-02

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Publication

Publication

Cell Metabolism , Volume 30 - Issue 1 p. 1- 2

Individuals with elevated LDL-cholesterol levels have an increased risk for cardiovascular disease. Despite lipid lowering strategies, however, a significant cardiovascular risk remains. Bekkering et al. show that monocytes from patients with familial hypercholesterolemia have a trained immunity phenotype and that lipid lowering with statins does not revert this pro-inflammatory phenotype.

Additional Metadata
Persistent URL doi.org/10.1016/j.cmet.2019.05.014, hdl.handle.net/1765/117558
Journal Cell Metabolism
Grant This work was funded by the European Commission 7th Framework Programme; grant id erc/310372 - The interaction landscape between microbial colonization and functional genome of the host: a systems biology approach in fungal infections (SYSBIOFUN)
Organisation Department of Internal Medicine
Citation
Bekkering, S. (Siroon), Stiekema, L.C.A. (Lotte C.A.), Bernelot Moens, S. (Sophie), Verweij, S.L. (Simone L.), Novakovic, B. (Boris), Prange, K. (Koen), … Riksen, N.P. (Niels P.). (2019). Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia. Cell Metabolism, 30(1), 1–2. doi:10.1016/j.cmet.2019.05.014


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