2019
Thyroid and Cardiovascular Disease Research Agenda for Enhancing Knowledge, Prevention, and Treatment
Publication
Publication
Circulation (Baltimore) , Volume 139 - Issue 25 p. 2892- 2909
ABSTRACT
Thyroid hormones have long been known to have
a range of effects on the cardiovascular system. However,
significant knowledge gaps exist concerning the precise molecular
and biochemical mechanisms governing these effects and the
optimal strategies for management of abnormalities in thyroid
function in patients with and without preexisting cardiovascular
disease. In September 2017, the National Heart, Lung, and Blood
Institute convened a Working Group with the goal of developing
priorities for future scientific research relating thyroid dysfunction
to the progression of cardiovascular disease. The Working Group
reviewed and discussed the roles of normal thyroid physiology, the
consequences of thyroid dysfunction, and the effects of therapy in
3 cardiovascular areas: cardiac electrophysiology and arrhythmias,
the vasculature and atherosclerosis, and the myocardium and
heart failure. This report describes the current state of the field,
outlines barriers and challenges to progress, and proposes research
opportunities to advance the field, including strategies for leveraging
novel approaches using omics and big data. The Working Group
recommended research in 3 broad areas: (1) investigation into the
fundamental biology relating thyroid dysfunction to the development
of cardiovascular disease and into the identification of novel
biomarkers of thyroid hormone action in cardiovascular tissues; (2)
studies that define subgroups of patients with thyroid dysfunction
amenable to specific preventive strategies and interventional therapies
related to cardiovascular disease; and (3) clinical trials focused on
improvement in cardiovascular performance and cardiovascular
outcomes through treatment with thyroid hormone or thyromimetic
drugs.
Additional Metadata | |
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doi.org/10.1161/circulationaha.118.036859, hdl.handle.net/1765/117811 | |
Circulation (Baltimore) | |
Organisation | Department of Epidemiology |
Cappola, A., Desai, AS, Medici, M., Cooper, L.S., Egan, D., Sopko, G., … Ladenson, P.W. (2019). Thyroid and Cardiovascular Disease Research Agenda for Enhancing Knowledge, Prevention, and Treatment. Circulation (Baltimore), 139(25), 2892–2909. doi:10.1161/circulationaha.118.036859 |