injury. However, the lack of a cognition dimension is generally felt as disadvantageous as many injuries involve cognitive effects. We aimed to assess the added value of a cognitive dimension in a cohort of injury patients. Methods We analyzed EQ-5D-3L extended with cognition (EQ-5D+C) dimension responses of 5346 adult injury patients. We studied dimension dependency, assessed the additional effect of the cognitive dimension on the EQ-VAS, and, using the EQ-VAS as a dependent variable, determined the impact of EQ-5D and EQ-5D+C attributes in multivariate regression analyses. Results Extreme cognitive problems combined with no problems on other dimensions are uncommon, whereas severe problems on other dimensions frequently occur without cognitive problems. The EQ-VAS significantly decreased when cognitive problems emerged. Univariate regression analyses indicated that all EQ-5D+C dimensions were significantly associated with the EQ-VAS. Exploratory analyses showed that using any set of five of the six EQ-5D+C dimensions resulted in almost identical explained variance, and adding the remaining 6th dimension resulted in a similar additional impact. Conclusions The addition of the cognition dimension increased the explanatory power of the EQ-5D-3L. Although the increase in explanatory power was relatively small after the cognition dimension was added, the decrease of HRQoL (measured with the EQ-VAS) resulting from cognitive problems was comparable to the decreases resulting from other EQ-5D dimensions.

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Keywords Health-related quality of life · EQ-5D · Injury · Trauma · Cognition
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Journal Quality of Life Research
Ophuis, R.H, Janssen, M.F, Bonsel, G.J, Panneman, M.J., Polinder, S, & Haagsma, J.A. (2019). Health-related quality of life in injury patients: the added value of extending the EQ-5D-3L with a cognitive dimension. Quality of Life Research, 28(7), 1941–1949. doi:10.1007/s11136-019-02156-2