Bio-nano interface investigation models are mainly based on the type of proteins present on corona, bio-nano interaction responses and the evaluation of final outcomes. Due to the extensive diversity in correlative models for investigation of nanoparticles biological responses, a comprehensive model considering different aspects of bio-nano interface from nanoparticles properties to protein corona fingerprints appeared to be essential and cannot be ignored. In order to minimize divergence in studies in the era of bio-nano interface and protein corona with following therapeutic implications, a useful investigation model on the basis of RADAR concept is suggested. The contents of RADAR concept consist of five modules: 1- Reshape of our strategy for synthesis of nanoparticles (NPs), 2- Application of NPs selected based on human fluid, 3- Delivery strategy of NPs selected based on target tissue, 4- Analysis of proteins present on corona using correct procedures and 5- Risk assessment and risk reduction upon the collection and analysis of results to increase drug delivery efficiency and drug efficacy. RADAR grouping strategy for revisiting protein corona phenomenon as a key of success will be discussed with respect to the current state of knowledge.

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Keywords Corona, Biological fluid, Bio-nano interface, Grouping strategy, Protein, RADAR
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Journal Colloids and Surfaces B-Biointerfaces
Rezaei, G., Daghighi, S.M., Haririan, I., Yousefi, I., Raoufi, M., Rezaee, F., & Dinarvand, R. (2019). Protein corona variation in nanoparticles revisited: A dynamic grouping strategy. Colloids and Surfaces B-Biointerfaces, 179, 505–516. doi:10.1016/j.colsurfb.2019.04.003