In the thesis entitled Photoacoustic imaging for Cardiovascular Applications, two cardiovascular diseases were tackled, namely atrial fibrillation and coronary atherosclerosis. An imaging algorithm was also devised to enhance imaging target super-localization. Photoacoustic imaging is an imaging modality which provides molecular information, based on optical absorption and subsequent thermoelastic expansion resulting in detectable pressure waves with common ultrasonic detectors. Capability of imaging tissue molecular changes was shown relevant to enable real-time monitoring of lesion formation in catheter-based ablation for atrial fibrillation as well as to assess lipid content of atherosclerotic plaques in an animal model in vivo. This thesis describes the development and design of the photoacoustic imaging system from instrumentation to realization in clinically translatable setups.

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Keywords Photoacoustic imaging, atrial fibrillation, intravascular photoacoustics, intracardiac photoacoustic, super-localization, image enhancement, ablation catheter, intravascular photoacoustic catheter, coronary atherosclerosis
Promotor A.F.W. van der Steen (Ton) , G. van Soest (Gijs)
Publisher Erasmus University Rotterdam
Sponsor This work was part of the perspectief program, instruments for Minimally Invasive Techniques, iMIT with project name Photoacoustic guidance for RF ablation of atrial Fibrillation, PARFAIT and project number 12706 which was financed by the Netherlands Organization for scientific Research (NWO)
ISBN 978-94-028-1581-8
Persistent URL
Note For copyright reasons there is a partial embargo for this dissertation
Iskander-Rizk, S. (2019, July 5). Photoacoustics for Cardiovascular Applications. Erasmus University Rotterdam. Retrieved from