Decades of prior genetic research using twin modelling designs has shown that differences in human behavior are strongly influenced by differences in our DNA. Through advances in DNA genotyping it has become feasible to study the genetic factors that contribute to human variation by large-scale genome-wide association studies (GWAS).
In this thesis, our aim was to study the genetic variants, genes and genetic pathways that explain variation in a broad diversity of behavioral outcomes making use of big data analyses in large population cohorts. By integrating GWAS results and GWAS-derived polygenic risk scores with gene-expression data, functional gene-sets and MRI imaging of the brain, this thesis provides a step forward in understanding the association between genetic variation and health-related phenotypes, including intelligence, neuroticism and depression, and insomnia, and the pathways and cell-types in the brain through which these genetic factors act.

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Keywords Genetics, epidemiology, psychiatric disorders, GWAS
Promotor F.C. Verhulst (Frank) , D. Posthuma (Danielle) , T.J.H. White (Tonya) , T.J.C. Polderman (Tinca)
Publisher Erasmus University Rotterdam
Sponsor The work presented in this thesis was made possible by financial support of the Sophia Foundation for Scientific Research (SSWO: Sophia Stiching voor Wetenschappelijk onderzoek), grant number S14-27
ISBN 978-94-028-1554-2
Persistent URL
Note For copyright reasons there is a partial embargo for this dissertation
Jansen, P.R. (2019, July 5). Population Studies of the Heritable Influences on the Mind and Brain. Erasmus University Rotterdam. Retrieved from