Objective: The worldwide increase in the incidence of syphilis necessitates alertness to the occurrence of neurosyphilis. Early recognition of neurosyphilis allows for timely treatment, leading to a better treatment outcome. This retrospective study aims to describe the clinical presentation of neurosyphilis in a recent series of neurosyphilis patients. Method: All patients were included with a new, laboratory confirmed, diagnosis of neurosyphilis in the period 2004-2018. The clinical data were analysed. Results: 34 neurosyphilis patients (1 woman and 33 men) were identified. Age varied from 31-84 years (median age: 44 years). A history of syphilis infection was known for 11 (32%) patients; 12 (35%) patients were HIV seropositive. The distribution of the clinical syndromes was as follows: 16 patients with early neurosyphilis (acute meningitis, meningovasculitis and/or uveitis), 9 patients with late neurosyphilis (General Paralysis of the Insane and/or Tabes Dorsalis), 2 patients with symptoms of both early and late neurosyphilis, 6 patients with asymptomatic neurosyphilis and in 1 patient insufficient data were available to determine a clinical syndrome. Early neurosyphilis was seen in all age categories, late neurosyphilis only occurred in patients 40 years. Conclusions: Neurosyphilis occurs in adults in all age groups, in men more frequent than in women, often in HIVinfected patients, and can present with a wide range of clinical syndromes. Usually no previous infection with syphilis is known.

Additional Metadata
Keywords Hiv co-infection, Neuropsychiatry, Neurosyphilis, Syphilis, Treponema pallidum
Persistent URL hdl.handle.net/1765/117940
Journal Clinical Neuropsychiatry: journal of treatments evaluation
Lens-Daey Ouwens, I.M, Ott, A, Fiolet, A.T.L, Koehler, P.J. (Peter J.), Vos, M. (Martin), Oldhoff, J.M. (J. Marja), & Verhoeven, W.M.A. (2019). Clinical presentation of laboratory confirmed neurosyphilis in a recent cases series. Clinical Neuropsychiatry: journal of treatments evaluation, 16(1), 17–24. Retrieved from http://hdl.handle.net/1765/117940