Impact of antithymocyte globulin on outcomes of allogeneic hematopoietic cell transplantation with TBI
The impact of the use of antithymocyte globulin (ATG) following a total body irradiation (TBI)–based myeloablative conditioning regimen has been poorly explored. We retrospectively analyzed 724 patients who underwent a first allogeneic hematopoietic cell transplantation (allo-HCT) following a TBI-based conditioning regimen for acute myeloid leukemia (AML) and compared the outcomes of 251 (35%) patients who received ATG (ATG group) with 473 (65%) patients who did not (non-ATG group). Median follow-up of surviving patients was 59 months (interquartile range, 28-83). The cumulative incidence of grade II-IV acute graft-versus-host disease (aGVHD) for non-ATG and ATG groups in the first 100 days was 33% vs 24%, respectively (P 5 .0098). The 2-year cumulative incidence of chronic graft-versus-host disease (cGVHD) was reduced significantly in the ATG group in comparison with the non-ATG group (46% vs 34%, P 5 .003). Using multivariate analysis, in vivo T-cell depletion (ATG group) was independently associated with a decreased incidence of grade II-IV aGVHD (hazard ratio [HR], 0.28; P, .001), grade III-IV aGVHD (HR, 0.21; P, .001), cGVHD (HR, 0.63; P 5 .02), and nonrelapse mortality (NRM) (HR, 0.54; P 5 .02). Relapse risk, overall survival, and leukemia-free survival were similar between the 2 groups. Our results suggest that the addition of ATG to TBI-based myeloablative conditioning for allo-HCT in AML patients results in a significant reduction in aGVHD and cGVHD, translating into a significant reduction in NRM without increasing the relapse rate.
|Persistent URL||dx.doi.org/10.1182/bloodadvances.2019000030, hdl.handle.net/1765/118066|
Nagler, A, Labopin, M, Dholaria, B. (Bhagirathbhai), Niittyvuopio, R. (Riitta), Maertens, J.A, Poiré, X, … Mohty, M. (2019). Impact of antithymocyte globulin on outcomes of allogeneic hematopoietic cell transplantation with TBI. Blood Advances, 3(13), 1950–1960. doi:10.1182/bloodadvances.2019000030