Characterization of Transcription Factor Complexes involved in Globin Gene Regulation

Most proteins mediate their function within macromolecular networks. Studies in model organisms suggest that such complex protein networks have topological and dynamic properties that reflect biological phenomena. Thus, an understanding of biological mechanisms and disease processes demands a ‘systems’ approach that goes beyond one-at-a time studies of single components to more global analyses of the structure, function and dynamics of the networks in which proteins function (Cusick, Klitgord et al. 2005).