2019-07-01
An Update on the Histology of Pheochromocytomas: How Does it Relate to Genetics?
Publication
Publication
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme , Volume 51 - Issue 7 p. 403- 413
Pheochromocytomas are rare neuroendocrine tumors of the adrenal gland, whereas any extra-adrenal tumor with similar histology is designated as paraganglioma. These tumors have a very high rate of germline mutations in a large number of genes, up to 35% to 40%, frequently predisposing for other tumors as well. Therefore, they represent a phenomenal challenge for treating physicians. This review focuses on pheochromocytomas only, with special attention to gross and microscopic clues to the diagnosis of genetic syndromes, including the role of succinate dehydrogenase subunit A and subunit B immunohistochemistry as surrogate markers for genetic analysis in the field of succinate dehydrogenase subunit gene mutations.
| Additional Metadata | |
|---|---|
| doi.org/10.1055/a-0672-1266, hdl.handle.net/1765/118532 | |
| Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme | |
| Organisation | Department of Pathology |
|
Oudijk, L., Gaal, J., Koopman, K. (Karen), & de Krijger, R. (2019). An Update on the Histology of Pheochromocytomas: How Does it Relate to Genetics?. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 51(7), 403–413. doi:10.1055/a-0672-1266 |
|