Genetic and non-genetic causes of Isolated Growth Hormone Deficiency and Combined Pituitary Hormone Deficiency: Results of the HYPOPIT study
Genetische en niet-genetische oorzaken van geïsoleerde groeihormoon deficiëntie en gecombineerde hypofyse hormoon deficiënties: resultaten van de HYPOPIT studie
Hypopituitarism, the deficiency of one or more pituitary hormones, causes stunted growth and severe health problems. Understanding the etiology of pituitary hormone deficiencies is important for anticipation of clinical problems, for genetic counselling and for possible prevention. This doctoral thesis describes the results of studies performed in patients with isolated growth hormone deficiency (IGHD) and combined pituitary hormone deficiencies (CPHD), in order to explore the genetic and non-genetic causes of pituitary hormone deficiencies and the phenotypic variability among patients.