2019
Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer
Publication
Publication
Biomarkers in Medicine , Volume 13 - Issue 10 p. 841- 850
Aim: To establish downregulated biomarkers for cross-resistance for radiotherapy (RT) in tamoxifen (TAM)-resistant breast cancer cells. Materials & methods: RNA sequencing was performed on TAM and RT-resistant breast cancer cells. Breast cancer patient cohorts were queried in silico for associations between genes of interest and outcome after TAM treatment or irradiation. Results: 20 genes showed decreased expression in both TAM-resistant and RT-resistant breast cancer cells. Only matrix Gla protein in the primary tumor was associated with outcome after TAM treatment or RT in breast cancer patients. Conclusion: Matrix Gla protein is a biomarker for therapy sensitivity in breast cancer.
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doi.org/10.2217/bmm-2019-0050, hdl.handle.net/1765/118600 | |
Biomarkers in Medicine | |
Post, A.E.M. (Annemarie E.M.), Bussink, J., Smid, M., Sweep, F., & Span, P. (2019). Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer. Biomarkers in Medicine, 13(10), 841–850. doi:10.2217/bmm-2019-0050 |