Aim: To establish downregulated biomarkers for cross-resistance for radiotherapy (RT) in tamoxifen (TAM)-resistant breast cancer cells. Materials & methods: RNA sequencing was performed on TAM and RT-resistant breast cancer cells. Breast cancer patient cohorts were queried in silico for associations between genes of interest and outcome after TAM treatment or irradiation. Results: 20 genes showed decreased expression in both TAM-resistant and RT-resistant breast cancer cells. Only matrix Gla protein in the primary tumor was associated with outcome after TAM treatment or RT in breast cancer patients. Conclusion: Matrix Gla protein is a biomarker for therapy sensitivity in breast cancer.

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Keywords irradiation, matrix Gla-protein, radiotherapy, tamoxifen treatment, treatment resistance
Persistent URL dx.doi.org/10.2217/bmm-2019-0050, hdl.handle.net/1765/118600
Journal Biomarkers in Medicine
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Citation
Post, A.E.M. (Annemarie E.M.), Bussink, J, Smid, M, Sweep, F.C, & Span, P.N. (2019). Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer. Biomarkers in Medicine, 13(10), 841–850. doi:10.2217/bmm-2019-0050